What is NEST?
NEST stands for "Nonsurgical Embryonic Selective Thinning and Transfer". It is a new treatment which was developed at our Institute, and is currently being studied.
Nonsurgical embryonic selective thinning and transfer is a technique for the active management of early embryonic growth and development. It utilizes newly defined growth media which facilitates embryonic cleavage. Selective thinning and transfer can be performed on the third day post ovum pickup when genetic competence may be more easily assessed on morphologic grounds. Unlike assisted hatching, selective thinning can also be performed on day 2 post ovum pickup, since the zona (the membrane surrounding the fertilized egg) is not fully breeched. The combination of embryonic thinning and selective transfer results in an increase in implantation rates, cycle fecundity rates, and overall pregnancy rates.
In a pilot study presented at the 1998 Pacific Coast Fertility Society Meeting, we demonstrated that these combined steps produced a 58% pregnancy rate in 16 consecutive patients, versus 26% in a comparable "control" group.
A description of NEST can be found in the July 1997 issue of "Cosmopolitan" Magazine.
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