IVF is an excellent option for couples with unexplained recurrent miscarriages. In cases in which I cannot pinpoint an etiology for the condition, I often recommend this approach. This is an important consideration at Fertility & Lifespan Medical Institute. The goal is to make sure that my patient can carry her pregnancy to term.
In cases where recurrent miscarriage is due to chromosomal abnormalities, IVF with preimplantation genetic testing (PGT-A) is beneficial. This process allows us to select the best embryos, i.e., those with no chromosomal abnormalities. This would improve the chance of a successful pregnancy.
One of the most important and distinct advantages of IVF is that it eliminates any negative effects of pelvic inflammation. This is because the egg is fertilized outside of the pelvis and the embryo transfer occurs outside of the uterus. Additionally, IVF can overcome ovulation disorders and PCOS, as well as tubal factor infertility, to reduce miscarriages.
Patients with recurrent miscarriages in association with endometriosis can benefit from IVF. Implants of endometriosis are associated with inflammation, increased oxidation, and exposure to cytotoxic chemicals. In vitro fertilization and embryo transfer eliminates the exposure of the egg or embryo to these factors.
In the uncommon cases where male factor infertility is the underlying cause of recurrent miscarriage, I recommend IVF with intracytoplasmic sperm injection (ICSI). Since this involves the injection of a single sperm directly into the egg, it facilitates the likelihood of fertilization. We can then test the resulting embryo for chromosomal abnormalities, and improve the chances of a successful pregnancy.
IVF allows us to determine the quality of embryos. If the embryo is excellent and has a normal number of chromosomes, then the failure to implant could indicate a hostile uterine environment, an immune disorder, or a clotting condition, which requires more intensive therapy.
IVF has both therapeutic and diagnostic advantages. It can identify problems in virtually all aspects of the reproductive process. Remarkably, it provides a way to identify the quality of eggs, the chromatin of sperm, fertilization, embryonic growth, chromosomal abnormalities, and implantation. Consequently, it is invaluable in situations in which recurrent miscarriages remain unexplained, and basic treatments fail.
Call the Infertility and Lifespan Medical Institute to schedule an appointment with Steven A. Brody, M.D., Ph.D.; Our Medical Director. Dr. Brody, authored the definitive textbook of IVF. He will review all of the pertinent factors relating to your fertility. All of the resources for assisted reproduction are available to help you achieve a healthy pregnancy, with the birth of your beautiful baby.
